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糖尿病周围神经病变(DPN)是糖尿病常见的慢性并发症,严重影响患者的生活质量。近年来,我们用葛根素治疗糖尿病周围神经病变56例,取得了良好的效果,现报道如下: 1 临床资料 1.1 对象:1999年4月～2001年5月住院的Ⅱ型糖尿病患者92例,其中男54例,女38例,年龄42～78岁,平均49±9岁;糖尿病病程10.8±6.3年,周围神经病程4.0±0.7年。治疗前1个月内血糖控制稳定,随机分为葛根素治疗组56例和对照组36例,两组病例无统计学差异。所有病例均符合以下诊断标准:①符合WHO糖尿病诊断标准;②有肢体感觉、运动神经病变表现,如四肢末梢感觉异常及/或感觉障碍,膝、跟腱反射减弱或消失;③肌电图检查显示正中神经、腓神经有传导障碍;④排除能导致周围神经病变的其他疾病。
Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes, seriously affecting the patient’s quality of life. In recent years, we use puerarin treatment of diabetic peripheral neuropathy in 56 cases and achieved good results are reported as follows: 1 Clinical data 1.1 Subjects: April 1999 ~ May 2001 hospitalized 92 cases of type II diabetes mellitus, of which 54 males and 38 females, aged 42 to 78 years, mean 49 ± 9 years; duration of diabetes 10.8 ± 6.3 years, peripheral neuropathy 4.0 ± 0.7 years. Blood glucose control within 1 month before treatment was stable and randomly divided into puerarin-treated group of 56 patients and control group of 36 patients. There was no significant difference between the two groups. All cases were in line with the following diagnostic criteria: ① meet WHO diagnostic criteria for diabetes; ② limbs, motor neuropathy, such as sensory dysfunction and / or sensory disturbances of the extremities, knee or Achilles tendon reflexes diminish or disappear; ③ Electromyography Show the median nerve, peroneal nerve conduction barrier; ④ exclude peripheral neuropathy can lead to other diseases.