目的:探讨颅脑外伤后精神障碍的相关病因以及临床治疗方法。方法:选取乐昌市人民医院、粤北第三人民医院、粤北第一人民医院2010年1月至2016年5月收治的50例颅脑外伤后精神障碍患者的临床资料;按照随机抽签法分为观察组、常规组,每组25例。两组均常规组施予药物治疗,观察组在常规治疗的基础上采取心理治疗和物理治疗,对两组治疗的效果以及复发率进行对比。结果:(1)治疗效果:观察组的总有效率为92%高于常规组的56%,差异具有统计学意义(P<0.05);(2)复发率:观察组的复发率为8.0%低于常规组的60.0%,差异具有统计学意义(P<0.05)。结论:颅脑外伤后精神障碍患者经药物、心理以及物理等联合治疗后,可获取良好的疗效,降低复发几率。 Objective: To explore the related etiology and clinical treatment of mental disorders after traumatic brain injury. Methods: The clinical data of 50 patients with mental disorders after traumatic brain injury admitted from January 2010 to May 2016 in Lechang City People’s Hospital, Third People’s Hospital of Yuebei and First People’s Hospital of North Guangdong Province were selected. According to random sampling Divided into observation group, conventional group, 25 cases in each group. Both groups were given conventional drug treatment, the observation group on the basis of conventional treatment to take psychological treatment and physical therapy, the two groups of treatment and recurrence rate were compared. Results: (1) Therapeutic effect: The total effective rate of the observation group was 92% higher than that of the conventional group (56%), the difference was statistically significant (P <0.05). (2) The recurrence rate: The recurrence rate of the observation group was 8.0% Lower than 60.0% of the conventional group, the difference was statistically significant (P <0.05). Conclusion: Patients with mental disorders after traumatic brain injury can get good curative effect and reduce the chance of recurrence after being combined with drugs, psychology and physical therapy.