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目的观察金水宝、别嘌醇与大黄苏打片三者联用治疗慢性痛风性肾病的临床疗效。方法 56例慢性痛风性肾病患者,随机分为治疗组和对照组,各28例。治疗组给予金水宝、别嘌醇与大黄苏打片三联治疗;对照组给予别嘌醇治疗,其他治疗两组相同。检测两组治疗前后血尿酸(UA)、尿素氮(BUN)、肌酐(SCr)、二氧化碳结合力(CO_2CP)、24 h尿蛋白定量水平;观察治疗期间痛风发作次数及不良反应。结果治疗2个月后,治疗组血UA、BUN、SCr、24 h尿蛋白定量下降水平明显高于对照组,两组比较差异有统计学意义(P<0.05)。两组间痛风性关节炎急性发作数、不良反应发生率比较差异无统计学意义(P>0.05)。结论在慢性痛风性肾病患者中,将金水宝、别嘌醇与大黄苏打片联用可增强疗效,值得临床推广应用。
Objective To observe the curative effect of Jinshui Bao, allopurinol and rhubarb soda tablet in the treatment of chronic gouty nephropathy. Methods 56 patients with chronic gouty nephropathy were randomly divided into treatment group and control group, 28 cases in each. The treatment group was given Jin Bao, allopurinol and rhubarb soda triple therapy; the control group was given allopurinol treatment, the other two groups were the same. The levels of serum UA, BUN, SCr, CO 2 CP and 24 h urinary protein were measured before and after treatment. The number of gout attacks and adverse reactions during the treatment were observed. Results After 2 months of treatment, the levels of UA, BUN, SCr and 24 h urinary protein in the treatment group were significantly lower than those in the control group. The difference was statistically significant (P <0.05). There was no significant difference in the number of acute attacks of gouty arthritis and incidence of adverse reactions between the two groups (P> 0.05). Conclusion In patients with chronic gouty nephropathy, the combination of Jinshuibao and allopurinol and rhubarb soda can enhance the curative effect and is worthy of clinical application.