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目的:了解2013年南京市区、郊区及周边地区新生儿溶血病发病情况。方法:对2013年南京市区、郊区及周边地区14家医院送检的1 430例疑似新生儿溶血病的血液标本检测结果进行分析。结果:1 430例标本主要来源于南京市区3家医院,其次为郊区及周边地区。新生儿溶血病总的阳性率为33.3%,市区医院阳性率低于郊区及周边地区。新生儿溶血病主要以ABO血型系统溶血为主,南京市区3家医院溶血血型系统种类较多;ABO血型系统溶血阳性标本中,母亲血清抗体效价>1∶64的占29.4%,其中周边地区的比例最高。另有检出13例C3d阳性标本。结论:新生儿溶血病是一种免疫性溶血性疾病,当新生儿出现黄疸症状或母子血型不合但未出现黄疸时,应及时送检,及早确定是否是新生儿溶血病,达到早发现早治疗的目的,对于新生儿生存以及生长发育有益无害。
Objective: To understand the incidence of hemolytic disease in newborns in Nanjing, suburbs and surrounding areas in 2013. Methods: The blood samples from 1 430 cases of hemolytic disease of newborn infested in 14 hospitals in Nanjing, suburbs and surrounding areas in 2013 were analyzed. Results: 1 430 specimens mainly came from 3 hospitals in Nanjing, followed by suburbs and surrounding areas. The overall positive rate of hemolytic disease in neonates was 33.3%. The positive rate in urban hospitals was lower than that in suburbs and surrounding areas. Hemolytic hemolytic disease is mainly dominated by hemolytic ABO blood group system, and there are more hemolytic blood group system in three hospitals in Nanjing. Among the hemolysis positive samples in ABO blood group, the serum antibody titers> 1:64 of the mother accounted for 29.4% The highest proportion of regions. Another 13 cases were detected C3d positive specimens. Conclusion: Neonatal hemolytic disease is an autoimmune hemolytic disease. When newborns have jaundice symptoms or maternal-child blood group incompatibility but jaundice has not appeared, they should be promptly inspected to determine if it is neonatal hemolytic disease, and early detection and early treatment The purpose of the newborn survival and growth and development beneficial and harmless.