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本文研究了Ⅰ类抗心律失常药丙吡胺(disopyramide)、慢心律(mexilitine)、茚丙胺(aprindine)对犬实验性心律失常模型的合并用药影响。实验结果表明,丙吡胺与慢心律两药的合并以及茚丙胺与慢心律两药的合并均能显著地对抗洋地黄所诱发的心律失常以及冠状动脉二步结扎法所诱发的心律失常,其效果均优于上述药物的单独应用。但是,对平均动脉血压和心率的影响,在单独应用和合并应用组之间无显著性差异单独应用丙吡胺时,其血中最高浓度为7.2μg/ml,丙吡胺对抗洋地黄性心律的失常的EC50
In this paper, we investigated the effects of disopyramide, mexilitine and aprindine, a class I antiarrhythmic drug, on the combination therapy of experimental arrhythmia models in dogs. The experimental results show that the combination of the two drugs, and the combination of the two drugs, both indomethacin and slow heart rhythm, can significantly antagonize the arrhythmia induced by digitalis and the arrhythmia induced by two-step coronary artery ligation. The results are better than the single application of the above drugs. However, the effect on mean arterial blood pressure and heart rate was no significant difference between monotherapy and pooled use alone when clomazone alone was used, with a maximum blood concentration of 7.2 μg / ml, with dipyridamole against digitalis The abnormal EC50