125例骨髓增生异常综合征免疫血液学检查阳性结果分析

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目的 对125例骨髓增生异常综合征(MDS)患者异常免疫血液学检查阳性结果 进行分析.方法 2010年1月-2019年12月收集患者的临床病史、输血信息及血清学检查结果 ,比较直接抗球试验(简称直抗)阳性与抗体筛查(简称抗筛)阳性患者的平均输血量、输血效果及输血强度.结果 77例直抗阳性患者中有41例合并抗筛阳性(占53.2%);68例抗筛阳性患者中有26例为Rh系统(占38.2%);直抗阳性患者红细胞人均输注量(U)高于抗筛阳性者(52.39 vs 36.94),而输血效果(输血前后血红蛋白值)及6个月前后红细胞输注总量却相反(P<0.01).21例血型抗原减弱中19例含有A抗原减弱.结论 MDS输血患者自身免疫紊乱与输血所致的同种免疫可互为影响互为加重,扩展表型匹配红细胞输血可以最小化同种免疫且可降低输血依赖.
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