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醋炔诺酮肟(2.5～5.0毫克/公斤/日)于妊娠第2天单次或第2、3天连续二次灌胃,可使小鼠卵子在输卵管(42.6～67.8%)运行提前一天进入子宫;但在妊娠第1天给予2.5毫克/公斤,则有76.6%卵子滞留于输卵管内,其中17.2%孕卵出现滞育现象(2细胞期)或异常。卵子移植实验表明,该药主要是抑制内膜分化,直接损伤胚泡作用较小。以醋炔诺酮肟1毫克/公斤/日给予妊娠第2和3天大鼠,第4天血清雌二醇峰、孕酮和子宫胞浆雌二醇受体水平均显著地受到抑制。提示醋炔诺酮肟可能通过加速小鼠卵子转运、干扰大鼠着床的激素平衡和抑制内膜分化,导致孕卵与内膜发育不同步,从而达到抗着床作用。
Acetic Norethindrone oxime (2.5 ~ 5.0 mg / kg / day) in the second day of pregnancy a single or 2, 3 days of continuous secondary gavage, the mouse egg in the fallopian tube (42.6 ~ 67.8%) run one day in advance However, when 2.5 mg / kg was given on the first day of gestation, 76.6% of the eggs were retained in the fallopian tube, of which 17.2% of the eggs showed diapause (2-cell stage) or abnormality. Eggs transplantation experiments show that the drug is mainly to inhibit intima differentiation, direct damage blastocyst smaller role. Administration of norgestimate oxone at 1 mg / kg / day on days 2 and 3 of pregnancy provided significant inhibition of serum estradiol peak, progesterone and uterine cytosolic estradiol receptors on day 4. It is indicated that norgetoxifloxacin may inhibit the implantation by accelerating mouse egg transport, interfering with the hormone balance of implantation and inhibiting the differentiation of intima, resulting in the asynchronous development of pregnant egg and intima.