目的:探讨缬沙坦、氢氯噻嗪联合用药治疗老年高血压的临床疗效。方法:分析150例老年原发性高血压患者临床资料,随机分为观察组与对照组;对照组服用缬沙坦80 mg/次,1次/d,观察组在对照组基础上服用氢氯噻嗪12.5mg/次,1次/d,两组均在晨起服用,服用疗程为6个月;检测治疗前后24h动态血压变化,并进行疗效判定,采用心脏彩色超声测定两组治疗前后左心室肌质量(LVM)、左心室重量指数(LVMI)变化。结果:观察组总有效率优于对照组,差异有统计学意义(P<0.05);两组治疗后24h平均SBP、DBP均较治疗前降低,观察组优于对照组,差异均有统计学意义(P<0.05);两组治疗后LVM、LVMI均较治疗前降低,观察组优于对照组,差异均有统计学意义(P<0.05)结论:氢氯噻嗪、缬沙坦联合用药可有效提高治疗效果,有效控制老年高血压患者血压水平,明显优于单药治疗,值得临床推广。 Objective: To investigate the clinical efficacy of valsartan combined with hydrochlorothiazide in the treatment of senile hypertension. Methods: The clinical data of 150 elderly patients with essential hypertension were randomly divided into observation group and control group. The control group was given valsartan 80 mg once daily, and the observation group was given hydrochlorothiazide 12.5 mg / time, once / d, both groups were taken in the early morning, taking a course of 6 months; 24h before and after treatment to detect ambulatory blood pressure, and to determine the efficacy of cardiac colorimetric determination of two groups before and after treatment of left ventricular muscle mass (LVM), left ventricular mass index (LVMI) changes. Results: The total effective rate of the observation group was better than that of the control group (P <0.05). The average SBP and DBP of 24h after treatment in both groups were lower than those before treatment, and the difference between the observation group and the control group was statistically significant (P <0.05). After treatment, the LVM and LVMI of both groups were lower than those before treatment, and the difference between the two groups was statistically significant (P <0.05) .Conclusion: Combination of hydrochlorothiazide and valsartan can effectively improve Therapeutic effect, effective control of blood pressure in elderly patients with hypertension was significantly better than single-drug treatment, it is worth clinical promotion.