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在多相分散体系的动力稳定性理论基础上,设计了以DEC-205单抗为导向、以脂质体为载体、DCs为靶点的免疫策略,将包裹药物的脂质体特异性地靶向树突状细胞(DCs).对影响DEC-205的免疫脂质体稳定性的各种因素如粒径分布等进行考察分析,对条件进行优化,构建了经DEC-205单抗靶向DCs的免疫脂质体模型.模型的成功构建为进一步研究抗原靶向DEC-205受体后的体内免疫应答情况提供了工作基础,有望开发一种新型DCs疫苗应用于临床.
Based on the theory of dynamic stability of heterogeneous dispersion system, we designed an immunization strategy that uses DEC-205 mAb as directing and liposome as carrier and DCs as target. The drug-encapsulated liposome specific target To dendritic cells (DCs) .Dec-205 immune liposome stability of various factors such as particle size distribution were investigated and analyzed, the conditions were optimized to construct the DEC-205 monoclonal antibody targeting DCs The successful construction of the model provides a foundation for further study of the immune response in vivo after the antigen targeting DEC-205 receptor, and is expected to develop a novel DCs vaccine for clinical application.