Flt3配体 (FL)是新近发现的、具有促进早期造血功能的细胞因子。在再生障碍性贫血、骨髓抑制等一系列造血功能障碍时 ,血清FL浓度升高 ,FL是评价造血功能的可靠指标之一。FL单用或与其它细胞因子联合应用 ,可以有效地扩增造血干 祖细胞 ,增加定向造血干 祖细胞及除红系以外的各系列血细胞。FL可有效地激发造血干 祖细胞进入细胞周期 ,因此 ,对以造血干 祖细胞为靶细胞的基因治疗具有重要意义。研究还发现 ,由于FL对DC细胞、NK细胞及CTL的刺激作用 ,其在体内具有显著的抗肿瘤作用。 Flt3 ligands (FLs) are newly discovered and have cytokines that promote early hematopoiesis. In aplastic anemia, bone marrow suppression and a series of hematopoietic dysfunction, serum FL concentration increased, FL is one of the reliable indicators of hematopoietic function. FL alone or in combination with other cytokines, can effectively expand hematopoietic stem and progenitor cells, hematopoietic stem cells and hematopoietic stem cells and red blood cells in addition to other series. FL can effectively stimulate the hematopoietic stem and progenitor cells into the cell cycle, therefore, to hematopoietic stem and progenitor cells target gene therapy is of great significance. The study also found that due to the stimulation of FL on DC cells, NK cells and CTL, it has a significant anti-tumor effect in vivo.