非类固醇抗炎药物(NSAIDs)已成为治疗儿童类风湿病的一部分,其抗炎特性部分在于抑制环氧化酶,该酶是花生四烯酸(AA)合成前列腺(PG)的主要酶。治疗儿童风湿病最常用NSAIDs有下列四类:1.水杨酸盐类;2.醋酸衍化物(如消炎痛、痛灭定和苏灵大);3.丙酸类(如萘普生、布洛芬和苯氧苯丙酸);4.其它药物(如甲氯灭酸钠盐)。 Non-steroidal anti-inflammatory drugs (NSAIDs) have become part of the treatment of rheumatoid arthritis in children and part of their anti-inflammatory properties are the inhibition of cyclo-oxygenase, a major enzyme in the synthesis of the prostate (PG) by arachidonic acid (AA). The four most commonly used NSAIDs for the treatment of rheumatoid arthritis in children are: 1. Salicylates; 2. Acetic acid derivatives such as indomethacin, piroxicam and sulindac; 3. propionic acids such as naproxen, Ibuprofen and phenyipropionate); 4. other drugs (such as meclofenamate sodium).