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目的研究难治性消化溃疡四联疗法治疗预后,以供临床参考应用。方法 200例难治性消化溃疡患者,采用随机对照的方法分为三联疗法组和四联疗法组,各100例。四联疗法组给予四联药物治疗,三联疗法组则给予三联药物治疗,治疗2个疗程后观察两组疗效。结果四联疗法组的治疗效果显著高于三联疗法组,差异具有统计学意义(P<0.05);四联疗法组患者临床症状消失时长明显短于三联疗法组,差异具有统计学意义(P<0.05)。结论难治性消化溃疡四联疗法治疗预后良好,跟三联疗法对比,能明显提高治疗效果,缩短症状消退时间,值得临床推广。
Objective To study the prognosis of refractory peptic ulcer quadruple therapy for clinical reference. Methods 200 patients with refractory peptic ulcer were randomly divided into triple therapy group and quadruple therapy group, with 100 cases each. The quadruple therapy group was given quadruple drug therapy while the triple therapy group was given triple drug therapy. After two courses of treatment, the curative effects of both groups were observed. Results The therapeutic effect of quadruple therapy group was significantly higher than that of triple therapy group (P <0.05). The duration of disappearance of clinical symptoms in quadruple therapy group was significantly shorter than that of triple therapy group (P < 0.05). Conclusion The treatment of refractory peptic ulcer with quadruple therapy has a good prognosis. Compared with triple therapy, it can significantly improve the therapeutic effect and shorten the time of symptom subsidence, which deserves clinical promotion.