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为探讨中药配合化疗对白血病的治疗价值,根据白血病化疗后多为虚实夹杂,既有热毒痰瘀又有气阴虚弱的见证,分别设复方中药清毒饮(由七叶一枝花、白花蛇舌草、山慈菇、莪术、胡黄连、大青叶、法半夏、竹茹、田七、生地、大黄、仙鹤草等组成)和养正片(由人参、黄芪、补骨脂、熟地、黄精、赤灵芝、女贞子、旱莲草、鸡内金、田七、虎杖、茜草根等组成),观察两方对环磷酰胺所致的造血抑制小鼠粒系造血的影响。观察指标:外周血白细胞计数、骨髓有核细胞计数及粒单系造血祖细胞培养。结果:两方均能提高外周血白细胞数、骨髓有核细胞数,养正片还能提高中性粒细胞百分数及粒单系造血祖细胞数。表明两方辅助化疗治疗白血病取效的机理可能分别是通过减轻化疗造成的骨髓抑制,改善粒系造血功能两个方面而实现的。
In order to explore the therapeutic value of traditional Chinese medicine combined with chemotherapy for leukemia, according to leukemia after chemotherapy is mostly virtual inclusions, both hot and weak qi and yin deficiency of the witness, respectively set the compound Chinese medicine Qing Du Yin (by the seven-leaf flower, white snake Tongcao, Cyperus rotundus, Curcuma, Huhuanglian, Daqingye, Pinellia, Zhuru, Tianqi, Rehmannia, Rhubarb, Agrimony, etc.) and Yangzheng (from ginseng, astragalus, psoralen, rehmannia, Huang Jing, Ganoderma lucidum, Ligustrum lucidum, Eclipta prostrata, Ji Nei Jin, Tian Qi, Polygonum cuspidatum, Radix Aconiti Lateralis, etc.) Observed the effects of both sides on hematopoietic suppression induced by cyclophosphamide in mice. Observed indicators: Peripheral blood leukocyte count, bone marrow nucleated cell count, and granulocyte hematopoietic progenitor cell culture. Results: Both of them can increase the number of peripheral white blood cells and bone marrow nucleated cells. The positive film can also increase the percentage of neutrophils and number of hematopoietic progenitor cells. It has been shown that the mechanism of the two-agent adjuvant chemotherapy in the treatment of leukemia may be achieved by reducing the bone marrow suppression caused by chemotherapy and improving the hematopoietic function of the granulocytic system.