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目的:分析甘参复方(甘草次酸与丹参酮配伍)防治大鼠免疫性肝纤维化的作用机制。方法:采用牛血清白蛋白静脉注射复制大鼠免疫性肝纤维化模型;以秋水仙碱为阳性对照药,灌胃给予高、中、低剂量的甘参复方防治,观察肝功能、肝组织羟脯氨酸含量、肝脏胶原纤维面积、血清补体C3含量和抗体IgE含量。结果:甘参复方降低肝脏羟脯氨酸含量(P<0.01),降低肝脏胶原纤维百分比(P<0.01),升高血清补体C3含量(P<0.01),降低血清IgE含量(P<0.01)。结论:甘参复方通过阻抑Ⅱ和Ⅲ型变态反应的启动环节,阻止Ⅰ型变态反应的延迟效应,发挥抗免疫性肝纤维化作用。
Objective: To analyze the mechanism of compound Ganshen compound (glycyrrhetinic acid combined with tanshinone) in preventing and treating immune fibrosis in rats. METHODS: Bovine serum albumin was intravenously injected to replicate the model of immune hepatic fibrosis in rats; colchicine was used as a positive control drug; high, medium and low doses of Ganshen compound were administered by gavage to observe liver function and liver tissue hydroxy. Proline content, liver collagen fiber area, serum complement C3 content and antibody IgE content. RESULTS: Ginseng compound decreased hepatic hydroxyproline content (P<0.01), reduced the percentage of liver collagen fibers (P<0.01), increased serum complement C3 content (P<0.01), and reduced serum IgE content (P<0.01). . Conclusion: Ginseng compound can prevent the delayed effect of type I allergic reaction by inhibiting the initiation of type II and type III allergic reactions and exert anti-immune hepatic fibrosis.