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目的:观察辛伐他汀、吡格列酮和苯磺酸左旋氨氯地平联合治疗代谢综合征疗效。方法:76例初诊代谢综合征患者,服用吡格列酮15mg/d、苯磺酸左旋氨氯地平2.5mg/d、辛伐他汀10mg/d,疗程1个月。观察治疗前后血压、腰围、体重指数、血糖、血胰岛素、血尿酸和血脂水平等变化。结果:患者治疗后血糖、血脂、胰岛素水平、血压均明显降低,差别有统计学意义(P<0.01)。腰围、体重指数略有下降,无统计学意义,血尿酸变化不明显。结论:吡格列酮、辛伐他汀和苯磺酸左旋氨氯地平联合治疗代谢综合征能够改善胰岛素抵抗和代谢异常,疗效可靠、服药简单、依从性好,效价比合理,无不良反应。
Objective: To observe the effect of simvastatin, pioglitazone and levoamlodipine besylate in the treatment of metabolic syndrome. Methods: 76 patients with newly diagnosed metabolic syndrome were treated with pioglitazone 15 mg / d, levamlodipine besylate 2.5 mg / d and simvastatin 10 mg / d for 1 month. Before and after treatment, blood pressure, waist circumference, body mass index, blood glucose, blood insulin, serum uric acid and blood lipid levels were observed. Results: After treatment, the blood glucose, blood lipids, insulin levels and blood pressure were significantly decreased (P <0.01). Waist circumference, body mass index decreased slightly, no statistical significance, blood uric acid change was not obvious. CONCLUSION: The combination of pioglitazone, simvastatin and levoamlodipine besylate can improve insulin resistance and metabolic abnormalities. The combination of pioglitazone, simvastatin and levamlodipine besylate can improve insulin resistance and metabolism. It has the advantages of simple medication, good compliance, reasonable titer and no adverse reactions.