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目的探讨食管原发性恶性黑色素瘤的临床病理学特征及诊断要点。方法对1例食管原发性恶性黑色素瘤进行组织学观察和免疫组化标记并相关文献复习。结果食管原发性恶性黑色素瘤与其他部位的恶性黑色素瘤组织学类型相似,免疫组化:瘤细胞HMB-45、S-100、Vimentin阳性;Cytokeratin(AE8),Cytokeratin(AE1/AE3),EMA,CgA阴性。结论食管原发性恶性黑色素瘤是一种罕见肿瘤,恶性度极差,应与一些食管原发肿瘤如低分化鳞状细胞癌、神经内分泌癌、间质肉瘤等相鉴别。
Objective To investigate the clinicopathological features and diagnosis points of esophageal primary malignant melanoma. Methods One case of primary esophageal malignant melanoma was observed by histology and immunohistochemically marked and reviewed. Results The primary malignant melanoma of esophagus was similar to histological types of malignant melanoma in other sites. Immunohistochemistry showed that the tumor cells were HMB-45, S-100 and Vimentin positive, Cytokeratin (AE8), Cytokeratin (AE1 / AE3) , CgA negative. Conclusions Esophageal primary malignant melanoma is a rare tumor with poor malignancy. It should be differentiated from some esophageal primary tumors such as poorly differentiated squamous cell carcinoma, neuroendocrine carcinoma and stromal sarcoma.