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目的：探讨乳腺癌组织微血管密度（ｍｉｃｒｏｖｅｓｅｌｄｅｎｓｉｔｙ，ＭＶＤ）及组织蛋白酶Ｄ（ｃａｔｈｅｐｓｉｎＤ，ＣＤ）表达与转移的关系。方法：应用免疫组织化学方法对乳腺癌组织的ＭＶＤ及ＣＤ进行定量和半定量研究。结果：乳腺癌组织ＭＶＤ及ＣＤ表达与淋巴结转移密切相关，腋下淋巴结转移组的ＭＶＤ（１３１．８±３９．８）明显高于腋下淋巴结阴性乳腺癌（ｎｏｄｅｎｅｇａｔｉｖｅｂｒｅａｓｔｃａｎｃｅｒ，ＮＮＢＣ）组的ＭＶＤ（７８．１±２７．１）（Ｐ＜０．００１）；腋下淋巴结转移组ＣＤ高表达者（３３／３６，９１．７％）明显多于ＮＮＢＣ组（１６／３６，４４．４％）（Ｐ＜０．０１）。乳腺癌组织ＭＶＤ与ＣＤ表达关系密切；远处转移及早期死亡者ＭＶＤ较高且ＣＤ表达极强。结论：乳腺癌组织ＭＶＤ的增加及ＣＤ高表达可能协同促进肿瘤转移。富于微血管及ＣＤ高表达的乳腺癌应作为远处转移及早期死亡的高危患者加以重视。
Objective: To investigate the relationship between microvessel density (MVD) and expression of cathepsin D (CD) in breast cancer. Methods: Quantitative and semi-quantitative studies of MVD and CD in breast cancer tissues were performed by immunohistochemistry. Results: MVD and CD expression in breast cancer tissues were closely related to lymph node metastasis. The MVD in the axillary lymph node metastasis group (131.8±39.8) was significantly higher than that in the adenoma negative breast cancer (NNBC) group (78 .1±27.1) (P<0.001); CD high expression in the axillary lymph node metastasis group (33/36, 91.7%) was significantly more than in the NNBC group (16/36, 44.4%) ( P<0.01). MVD is closely related to CD expression in breast cancer tissues; distant metastasis and early death are higher in MVD and CD expression is stronger. Conclusion: The increase of MVD and the high expression of CD in breast cancer may synergistically promote tumor metastasis. Breast cancers rich in microvessels and high expression of CD should be considered as high-risk patients with distant metastasis and early death.