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糖尿病是一组病因和发病机制尚未完全阐明的内分泌-代谢疾病,而以高血糖为其共同主要标志。因胰岛素分泌绝对或相对不足以及靶细胞对胰岛素敏感性降低,引起糖、蛋白质、脂肪和继发性的水、电解质代谢紊乱。 糖尿病并发症是常见的,其发病机制及其与糠尿病代谢紊乱之间的关系也尚未确切阐明。近年来在研究人们高血糖的基础上进一步阐明了非酶糖化的发展和醛糖还原酶葡萄糖毒性的理论。本文将主要涉及糖基化蛋白和氧自由基在糖尿病和糖尿病并发症中的作用。
Diabetes mellitus is a group of endocrine-metabolic diseases that have not yet been completely elucidated in the etiology and pathogenesis, but hyperglycemia is their common main hallmark. Due to absolute or relative lack of insulin secretion and target cells to reduce insulin sensitivity, causing sugar, protein, fat and secondary water, electrolyte metabolism disorders. Diabetic complications are common, and its pathogenesis and the relationship between metabolic disorders and diabetes have not yet been clarified. In recent years, based on the study of hyperglycemia in people further elucidate the development of non-enzymatic glycation and aldose reductase glucose toxicity theory. This article will mainly deal with the role of glycosylated proteins and oxygen free radicals in the complication of diabetes mellitus and diabetes mellitus.