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目的观察拜糖平联合舒降之对中青年2型糖尿病(T2DM)的疗效及对胰岛素抵抗(IR)的影响。方法对60例服用拜糖平和舒降之的中青年T2DM患者,采用WHO推荐方法进行葡萄糖耐量试验(OGTT),分别测定中青年T2DM患者的空腹血糖(FPG)与空腹胰岛素(FIN),将它们乘积的倒数作为(ISI)IR的指标,计算其曲线下面积AUC(FPG)和AUC(FIN),并记录血脂、血压、身高体重指数。结果经治疗后后糖尿病患者血糖、血脂、血压、AUC(FGP)面积下降,ISI值上升,差异有显著性(P<0.05)。AUC(FIN)治疗前后差异无显著性,(P>0.05)。结论拜糖平联合舒降之不仅能明显改善血糖及血脂代谢状况,还能改善中青年T2DM患者的胰岛素抵抗,对于其余年龄段的患者作用有待进一步研究。
Objective To observe the curative effect and the effect on the insulin resistance (IR) of middle and young type 2 diabetes mellitus (T2DM) treated with aldosteron and albupid. Methods Sixty middle-aged and young patients with T2DM were treated with Oral Topiramate (OGTT). The fasting blood glucose (FPG) and fasting insulin (FIN) were measured in young and middle-aged patients with T2DM. The inverse of the product was used as an index of (ISI) IR, and the area under the curve AUC (FPG) and AUC (FIN) were calculated. Blood lipids, blood pressure and body mass index were recorded. Results After treatment, the area of blood glucose, blood lipids, blood pressure, AUC (FGP) of diabetic patients decreased and the ISI increased. The difference was significant (P <0.05). There was no significant difference in AUC (FIN) before and after treatment (P> 0.05). Conclusion Baipan combined with Shuzheng not only can significantly improve blood glucose and lipid metabolism, but also improve insulin resistance in middle-aged and young patients with T2DM, the role of the rest of the age needs further study.