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目的探讨老年糖尿病患者脂蛋白(a)Lp(a)和凝血指标变化的临床意义。方法测定50例老年糖尿病患者和28例糖尿病合并脑梗塞患者的Lp(a)和凝血指标:纤维蛋白原(Fbg)、凝血酶原时间(PT)、部分活化凝血酶时间(APTT)。结果糖尿病组及糖尿病合并脑梗塞组患者较正常组Lp(a)、Fbg显著升高(P < 0.05),PT、APTT明显缩短(P <0.05)。结论糖尿病患者体内存在高凝状态,Lp(a)升高可加重其病理生理过程,共同参与糖尿病的血管并发症的发生,易致血栓形成。
Objective To investigate the clinical significance of the changes of lipoprotein (a) Lp (a) and coagulation index in elderly patients with diabetes mellitus. Methods The Lp (a) and coagulation indexes of fibrin (Fbg), prothrombin time (PT) and partial activated thrombin time (APTT) in 50 elderly diabetic patients and 28 diabetic patients with cerebral infarction were measured. Results The levels of Lp (a) and Fbg in diabetic group and diabetic cerebral infarction group were significantly higher than those in normal group (P <0.05), but PT and APTT were significantly shorter (P <0.05). Conclusion There is a hypercoagulable state in diabetic patients. Elevated Lp (a) may aggravate its pathophysiological process and participate in the occurrence of vascular complications of diabetes and cause thrombosis.