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目的探讨肾炎康复片联合氯沙坦钾治疗慢性肾小球肾炎的疗效及对血清白细胞诱素1(LKN-1)、肿瘤坏死因子α(TNF-α)和白细胞介素33(IL-33)的影响。方法选择2011年9月至2014年11月重庆市第五人民医院接诊的慢性肾小球肾炎患者100例。按照随机数字表法分为对照组和观察组,各50例。两组患者均进行常规治疗(预防感染以及注意休息)与抗凝治疗。对照组在常规治疗的基础上给予氯沙坦钾治疗,每次50 mg,每日1次;观察组在对照组的基础上加用肾炎康复片治疗,每次200 mg,每日3次。比较两组患者治疗后的临床疗效,测定治疗前后血清LKN-1、TNF-α和IL-33水平,尿蛋白定量及肾功能改善情况。结果观察组的总有效率显著高于对照组[92.0%(46/50)比68.0%(34/50)],差异有统计学意义(P<0.01);观察组血清中的LKN-1、TNF-α和IL-33均显著低于对照组[(71±20)pmol/L比(132±44)pmol/L,(0.17±0.05)pg/L比(0.40±0.13)pg/L,(68±18)pmol/L比(100±26)pmol/L],差异有统计学意义(P<0.01);观察组尿蛋白显著低于对照组[(1350±210)mg比(1770±270)mg],差异有统计学意义(P<0.05);两组治疗后肾功能指标比较差异无统计学意义(P>0.05)。结论肾炎康复片联合氯沙坦钾治疗慢性肾小球肾炎的效果良好,能够有效降低血清中LKN-1、TNF-α和IL-33水平,值得临床推广。
Objective To investigate the effects of nephritis and kangshen tablets combined with losartan on the treatment of chronic glomerulonephritis and the effects on the serum levels of LKN-1, TNF-α and IL-33, Impact. Methods From September 2011 to November 2014, 100 patients with chronic glomerulonephritis admitted to the Fifth People’s Hospital of Chongqing were enrolled. According to random number table divided into control group and observation group, 50 cases each. Both groups received routine treatment (prevention of infection and attention to rest) and anticoagulation therapy. The control group received losartan potassium on the basis of routine treatment, each time being 50 mg once daily. The observation group was treated with nephritis kangshen tablets on the basis of the control group, each time 200 mg three times a day. The clinical effects of two groups of patients after treatment were compared. The levels of serum LKN-1, TNF-α and IL-33, urinary protein and renal function were measured before and after treatment. Results The total effective rate of the observation group was significantly higher than that of the control group (92.0% (46/50) vs. 68.0% (34/50)], with significant difference (P <0.01). The serum levels of LKN- (71 ± 20) pmol / L (132 ± 44) pmol / L, (0.17 ± 0.05) pg / L pg / L and 0.40 ± 0.13 pg / (68 ± 18) pmol / L (100 ± 26) pmol / L], the difference was statistically significant (P <0.01). Urinary protein in the observation group was significantly lower than that in the control group [(1350 ± 210) mg 270) mg], the difference was statistically significant (P <0.05). There was no significant difference in renal function between the two groups after treatment (P> 0.05). Conclusion Shenyinkang tablets combined with losartan potassium treatment of chronic glomerulonephritis good effect, can effectively reduce the serum levels of LKN-1, TNF-α and IL-33, worthy of clinical promotion.