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[目的]了解福建省胃癌中低发地区居民血清PGⅠ、PGⅡ、G-17和Hp感染水平分布特征,探讨用上述血清学标志物筛查高危人群的可能性。[方法]在同安区和福安市随机抽取调查对象进行问卷调查,检测血清PGⅠ、PGⅡ、G-17和Hp感染水平。[结果]PGⅠ水平呈明显的性别、年龄、地区分布差异,PGⅡ、PGⅠ/PGⅡ水平呈明显的地区分布差异。不同Hp感染状态下PGⅠ、PGⅡ、PGⅠ/PGⅡ、G-17水平呈明显差异(P均<0.05)。Logistic回归分析未发现影响PGⅠ、PGⅠ/PGⅡ水平异常的因素,但G-17水平异常的危险因素为Hp感染(OR=2.656)和中年年龄(OR=2.114)。[结论]PGⅠ、PGⅡ、G-17筛查胃癌高危人群具有较广阔的前景。
[Objective] To investigate the distribution characteristics of serum PGⅠ, PGⅡ, G-17 and Hp in residents with low-grade gastric cancer in Fujian province and explore the possibility of using these serological markers to screen high-risk population. [Method] Questionnaires were randomly selected in Tong'an District and Fu'an City to investigate the serum levels of PGⅠ, PGⅡ, G-17 and Hp. [Results] The level of PGⅠwas obviously different according to sex, age and geographical distribution. The differences of PGⅡ and PGⅠ / PGⅡ were obvious in different regions. The levels of PGⅠ, PGⅡ, PGⅠ / PGⅡ and G-17 in different Hp infection groups were significantly different (all P <0.05). Logistic regression analysis found no abnormal factors of PGⅠ and PGⅠ / PGⅡ, but the risk factors of abnormal G-17 levels were Hp infection (OR = 2.656) and middle age (OR = 2.114). [Conclusion] PGⅠ, PGⅡ, G-17 screening of high-risk groups of gastric cancer has a broader perspective.