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目的:通过观察温肾化石汤对含钙尿石形成相关指标的影响,探讨该方防治含钙尿石形成的机理,为防治含钙尿石复发开创新思路,提供新方法。方法:SD雄性大鼠40只,随机分为4组:A空白对照组,B模型组,C1温肾化石汤高剂量组,C2温肾化石汤低剂量组。除A组外,其它各组喂标准鼠料,饮用含0.75?乙二醇和0.75-氯化铵的自来水。温肾化石汤按30g/kg、15g/kg剂量给C组灌胃。A组、B组灌自来水。各组均饲养6周。检测各组大鼠的肾功能、尿草酸、钙的含量,并观察肾组织结构的变化及草酸钙晶体的分布。结果:“温肾化石汤”可以显著降低尿中钙、草酸等尿石形成促进物的含量;增加的尿石形成抑制物镁的含量(P<0.01),草酸钙晶体形成程度、肾组织细胞的损伤程度明显减轻。结论:温肾化石汤可以保护肾脏组织结构,对草酸钙晶体形成有明显的抑制作用。
OBJECTIVE: To observe the effect of Wenshen Fushi Decoction on the related indicators of calcium-containing urolithiasis, discuss the mechanism of prevention and treatment of calcium-containing uroliths, and provide a new way to prevent recurrence of calcium-containing uroliths. Methods: Forty SD male rats were randomly divided into four groups: A blank control group, B model group, C1 Wenshen Fossil Decoction high-dose group and C2 Wenshen Fossil Decoction low-dose group. Except for group A, the other groups fed standard rat material, drinking tap water containing 0.75 乙 glycol and 0.75 ammonium chloride. Wenshen fossil soup by 30g / kg, 15g / kg dose to the C group gavage. Group A, Group B irrigation tap water. All groups were housed for 6 weeks. The renal function, urinary oxalate and calcium contents of rats in each group were detected. The changes of renal tissue structure and the distribution of calcium oxalate crystals were observed. Results: “Wenshen Fossil Decoction” can significantly reduce urinary calcium, oxalic acid and other urinary formation promoters; increased urinary stone formation inhibitory magnesium content (P <0.01), the formation of calcium oxalate crystals, kidney Tissue cells significantly reduce the degree of damage. Conclusion: Wenshen Fossil Decoction can protect the structure of kidney and inhibit the formation of calcium oxalate crystals.