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目的分析儿童呼吸道合胞病毒感染后T细胞亚群变化情况。方法选择儿童呼吸道合胞病毒感染患者34例为观察组,并选取同期健康体检小儿35例为对照组,在明确诊断后检测两组患者外周血淋巴细胞亚群及T淋巴细胞亚群。结果观察组Th1和Th2比率均高于对照组(P<0.05),Th1/Th2则低于对照组(P<0.05),观察组外周血T淋巴细胞亚群中CD3+和CD8+低于对照组(P<0.05),CD4+高于对照组(P<0.05),且CD4+/CD8+高于对照组(P<0.05)。结论小儿呼吸道合胞病毒性毛细支气管炎与小儿哮喘的T细胞亚群及Th1/Th2功能变化存在相似性,两者发病机制之间存在一定的关联性。
Objective To analyze the changes of T cell subsets in children with respiratory syncytial virus infection. Methods 34 cases of children with respiratory syncytial virus infection were selected as the observation group. 35 healthy children were selected as the control group during the same period. The peripheral blood lymphocyte subsets and T lymphocyte subsets of the two groups were detected after definite diagnosis. Results The Th1 and Th2 ratios in the observation group were significantly higher than those in the control group (P <0.05), and those in the control group were significantly lower than those in the control group (P <0.05). The levels of CD3 + and CD8 + in the T lymphocyte subsets in the observation group were lower than those in the control group (P <0.05). CD4 + was higher than that of control group (P <0.05), and CD4 + / CD8 + was higher than that of control group (P <0.05). Conclusion There are similarities in the changes of T cell subsets and Th1 / Th2 functions between pediatric respiratory syncytial virus bronchiolitis and pediatric asthma. There is a certain relationship between the two pathogenesis.