目的：探讨妊娠肝内胆汁瘀积症（ICP）胎儿宫内缺氧情况的动态观察及处理，做好围产期保健，降低胎儿病死率。方法；对154例ICP患者血清甘胆酸、肝功能、无激惹试验（NST）、B超等检查，并将其与妊娠结局进行分析。结果：血清甘胆酸值显著升高且血清转氨酶和脸红素同时升高、NST胎心基线率变异消失者羊水污染率、胎儿宫内窘迫率分别高于单纯转氨酶升高而胆红素值正常、NST胎心基线率变异正常老。 Objective: To investigate the dynamic observation and treatment of intrauterine hypoxia in intrahepatic cholestasis of pregnancy (ICP), improve the perinatal health and reduce the fetal mortality rate. Methods: 154 cases of ICP patients with serum glycocholate, liver function, no irritation test (NST), B ultrasound examination, and pregnancy and pregnancy outcomes were analyzed. Results: Serum glycocholic acid increased significantly and serum aminotransferase and leptin increased at the same time. Amniotic fluid contamination rate and fetal distress rate of NST fetal heart rate variability disappeared were higher than those of pure aminotransferase and normal bilirubin , NST fetal heart rate variability normal old.