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抗癌药博莱霉素可与DNA结合,然后再打开DNA链。博莱霉素是从轮状链霉菌分离的,用来治疗肿瘤已有数年,特别是用来治疗头部和喉部肿瘤。它是数种糖肽类的混合物(带糖残基的短蛋白链),其中某些糖肽类已被分离和鉴定。博莱霉素A_2是主要成分,结构复杂,但主要是由结合不同环的多肽链组成。关于该药如何攻击肿瘤的问题,已进行了15年的研究。博莱霉素通过四个不同的阶段发挥其作用。首先,分子吸附一个铁原子(Fe),然后牢牢抓在肿瘤的DNA上,这样才能攻击、
The anticancer drug bleomycin can bind to DNA and then open the DNA strand. Bleomycin is isolated from Streptomyces robur, and has been used to treat tumors for several years, especially for the treatment of head and throat tumors. It is a mixture of several glycopeptides (short protein chains with sugar residues), some of which have been isolated and identified. Bleomycin A_2 is the main component and its structure is complex, but it is mainly composed of polypeptide chains that bind different rings. The issue of how the drug attacks tumors has been studied for 15 years. Bleomycin exerts its effect through four different phases. First, the molecule adsorbs an iron atom (Fe) and then firmly grips the DNA of the tumor so that it can attack,