本文报道国产氧氟沙星对临床分离的618株致病菌的体外抗菌活性研究结果,并与环丙沙星、培氟沙星、依诺沙星和诺氟沙星进行比较。结果表明氧氟沙星、培氟沙星和环丙沙星对金葡球菌和表葡球菌均敏感,其抑菌率分别为100％、99％和99.1％;5种喹诺酮类药物对肠杆菌科细菌显示明显的抗菌活性;对绿脓杆菌的抗菌活性以环丙沙星最强,抑菌率为90.90％;5种氟喹诺酮类药物对产β-内酰胺酶的阳性和阴性细菌,其抗菌活性基本一致。 This article reports the in vitro antibacterial activity of ofloxacin against 618 pathogens isolated from clinical isolates and compared with ciprofloxacin, pefloxacin, enoxacin and norfloxacin. The results showed that ofloxacin, pefloxacin and ciprofloxacin were sensitive to Staphylococcus aureus and Staphylococcus epidermidis, the antibacterial rates were 100%, 99% and 99.1%; 5 quinolones on Enterobacteriaceae Division bacteria showed significant antibacterial activity; the antibacterial activity of Pseudomonas aeruginosa with ciprofloxacin strongest, antibacterial rate was 90.90%; 5 fluoroquinolones producing β-lactamase-positive and negative bacteria, which Antibacterial activity is basically the same.