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在兰州市随机采集的２１６名健康婴幼儿粪标本经分离并对其培养特性、菌落菌体形态特征、生化反应特性以及毒素原性等进行一系列检查，检出了３７人的粪便含有艰难梭菌（１０４─１０８／ｇ），检出总阳性率为１７．１％，新生儿、婴儿及幼儿各年龄组的检出阳性率分别为１３．５％（１９／４１）、３３．３％（１３／３９）、１３．９％（５／３６）。３７株分离菌中毒素原性阳性者仅有８株（２１．６％），均分布于婴儿与幼儿两组。新生儿１４１人中２７人的粪标本为胎粪，只有１人（３．７％）含艰难梭菌（２×１０６／ｇ），但不产毒素。所有婴幼儿中有２２人因各种原因曾用过抗菌药物，但仅有２人的粪便含艰难梭菌，而且均为非产毒株，表明艰难梭菌检出率与药物服用之间似无显著的相关性。
A total of 216 healthy infant and youngster samples collected from Lanzhou City were isolated and tested for a series of tests on their culture characteristics, colony morphology, biochemical reaction characteristics and toxinogenicity. 37 fecal samples were found to contain difficult shuttle (104- 108 / g), the positive rate was 17.1%, the positive rates of neonates, infants and young children were 13.5% (19/41), 33.3% (13/39), 13.9% (5/36). Of the 37 isolates, only 8 (21.6%) were toxoid positive were found in both infants and young children. Of the 141 newborns, 27 had fecal specimens of meconium, and only 1 (3.7%) contained C. difficile (2x106 / g), but no toxins were produced. Of all infants and young children, 22 used antimicrobial agents for a variety of reasons, but only 2 of their feces contained Clostridium difficile and were non-toxigenic, indicating that the detection rate of C. difficile is similar to that of taking the drug No significant correlation.