视网膜胚细胞瘤蛋白(retinoblastoma protein,RB)是一个110 kD的核磷酸蛋白。在许多人恶性肿瘤中发现,该蛋白由于基因发生缺失和突变而失活,表明它与细胞恶性变过程有密切的联系。近年来发现RB还可与许多细胞蛋白结合并抑制细胞的生长,其抑制作用在细胞周期中受磷酸化的调节,该调节又与几个RB激酶有关。 Retinaloblastoma protein (RB) is a 110 kD nuclear protein. It is found in many human malignancies that the protein is inactivated due to gene deletion and mutation, indicating that it is closely related to the process of cell malignant transformation. In recent years, it has been found that RB can also bind to many cellular proteins and inhibit the growth of cells. Its inhibitory effect is regulated by phosphorylation in the cell cycle, which in turn is related to several RB kinases.