目的探讨高强度聚焦超声(HIFU)治疗良性占位性疾病的价值、疗效和不良反应。方法选择拒绝或惧怕手术的子宫肌瘤、前列腺肥大、乳腺纤维腺瘤或结节性增生,卵巢实性占位等患者,采用HIFUNIT9000型超声聚焦肿瘤消融机,在B超定位并监视下,通过6个换能器三维适形优化组合治疗方案,使靶区点点成线,线线成面,面面成体逐渐固化覆盖瘤体。结果476例患者(肌瘤370例410个瘤灶、子宫腺肌症50例、前列腺肥大26例、卵巢实性占位10例,乳腺纤维腺瘤或结节增生20例),治疗后瘤体内回声较前增高不均,瘤体内血流信号减少或消失,体积逐渐缩小,临床症状改善或恢复正常。随访1年以上,体积明显缩小或消失37%,缩小46.8%,无变化16%,增大0.2%。结论HIFU治疗良性占位或前列腺增生病,是一种无创无辐射有效安全的方法,值得推广应用。 Objective To investigate the value, efficacy and adverse reactions of high intensity focused ultrasound (HIFU) in the treatment of benign space-occupying diseases. Methods: Patients with uterine fibroids, benign prostatic hypertrophy, fibroadenoma of the breast, or nodular hyperplasia and ovarian real mass occupations, which were rejected or afraid of surgery, were treated with HIFUNIT 9000 ultrasonography focused tumor ablation machine, 6 transducer three-dimensional conformal optimization combination treatment program, the target area of ​​a little line, line into a surface, the surface gradually solidified body covered tumor. Results 476 patients (fibroids 370 cases 410 lesions, adenomyosis 50 cases, 26 cases of benign prostatic hyperplasia, ovarian solid mass in 10 cases, breast fibroadenoma or nodular hyperplasia 20 cases), after treatment, the tumor Echoes increased uneven than before, the tumor blood flow signal to reduce or disappear, the volume gradually reduced, the clinical symptoms improved or returned to normal. Follow-up more than 1 year, the volume was significantly reduced or disappeared 37%, 46.8% reduction, no change 16%, an increase of 0.2%. Conclusion HIFU treatment of benign or benign prostatic hyperplasia, is a non-invasive radiation-free effective and safe method, it is worth promoting.