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目的:分析卵泡期长效长方案在符合卵巢高反应预测指标患者中的运用及高反应发生的危险因素。方法:运用病例对照研究方法，回顾性分析2016年1月1日至2019年6月1日期间于福建省妇幼保健院生殖中心就诊的符合卵巢高反应预测指标的664例患者的临床资料。通过logistic回归，筛选卵巢高反应的独立危险因素。运用受试者工作特征曲线下面积 （area under the curve， AUC）评估所筛选各卵巢高反应独立危险因素的预测准确度。结果:664例患者中10例（1.51%）发生卵巢低反应，356例患者（53.61%）取得正常的卵巢反应，298例患者（44.88%）发生高反应。正常反应组的中重度卵巢过度刺激综合征发生率［3.09%（11/356）］显著低于高反应组［8.39%（25/298）， n P=0.003］；每移植周期临床妊娠率与高反应组间差异无统计学意义（n P>0.05）；高反应组流产率为正常反应组的2倍多，但差异无统计学意义（n P>0.05）。多因素logistic回归提示人绒毛膜促性腺激素（human chorionic gonadotropin， hCG）注射日黄体生成素（luteinzing hormone， LH）水平与卵巢高反应的发生呈显著负相关。hCG注射日LH水平预测卵巢高反应发生的AUC为0.594，hCG注射日LH水平≤1.0 IU/L是高反应发生的独立危险因素。n 结论:卵泡期长效长方案运用于符合卵巢高反应预测指标的患者可获得较为理想的临床结局。控制性卵巢刺激过程中适当添加外源性LH可能有助于减少卵巢高反应的发生。“,”Objectives:To investigate the clinical outcomes of long agonist protocol in predicted hyper responders, and to explore the risk factors associated with hyper ovarian response in these patients.Methods:In this retrospective case-control study, 664 predicted hyper responders were included. All patients were from Reproductive Center of Fujian Maternity and Child Health Hospital, and were in treatment during January 1, 2016 and June 1, 2019. Logistic regression was applied to screen out the independent risk factors of hyper ovarian response. The prediction accuracy of the independent risk factors was evaluated by calculating the area under the receiver operating characteristic curve (AUC).Results:Totally 10 (1.51%) of all patients occurred poor ovarian response, 356 (53.61%) of all patients achieved normal ovarian response, and 298 (44.88%) of them got hyper ovarian response. The rate of moderate-to-severe ovarian hyperstimulation syndrom (OHSS) from normal response group [3.09% (11/356)] was significantly lower than that from hyper response group [8.39% (25/298),n P=0.003]. The rate of clinical pregnancy per transfer showed no statistical significance between the two groups (n P>0.05). The miscarriage rate was more than two times in normal response group compared with high response group, but without statistical significance (n P>0.05). Multivariate logistic regression analysis showed that luteinizing hormone (LH) level on human chorionic gonadotropin (hCG) injection day was negatively correlated with the occurrence of hyper ovarian response. The AUC of LH level on hCG injection day was 0.594. LH level on hCG injection day ≤1.0 IU/L was an independent risk factor of hyper ovarian response.n Conclusion:Long agonist protocol is a good option for predicted hyper responders. LH supplementation might be helpful in controlled ovarian stimulation to reduce the incidence of hyper ovarian response.