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目的探讨IL-27在慢性乙型肝炎感染者外周血中的表达及临床意义。方法应用酶联免疫吸附法(ELISA)对61例慢性乙型肝炎(CHB)患者、51例肝硬化(LC)患者、29例肝细胞癌(HCC)患者及50例正常对照者血清IL-27表达水平进行检测。结果 CHB组、LC组及HCC组血清IL-27表达水平均显著高于正常对照组(P<0.001);LC组IL-27表达水平显著高于CHB组及HCC组(P<0.001);HBV感染者IL-27表达水平与TBil呈正相关;CHB组IL-27表达水平与ALT呈正相关;LC组IL-27表达水平与AST及TBil均呈正相关。结论 IL-27在慢性HBV感染者外周血中呈高表达,且在慢性HBV感染进程中与肝脏炎症损伤相关。
Objective To investigate the expression of IL-27 in peripheral blood of patients with chronic hepatitis B infection and its clinical significance. Methods Serum levels of IL-27 in 61 patients with chronic hepatitis B (CHB), 51 patients with cirrhosis (LC), 29 patients with hepatocellular carcinoma (HCC) and 50 normal controls were detected by enzyme-linked immunosorbent assay (ELISA) Expression level for testing. Results The serum levels of IL-27 in CHB group, LC group and HCC group were significantly higher than those in normal control group (P <0.001). The expression of IL-27 in LC group was significantly higher than that in CHB group and HCC group (P <0.001) The expression of IL-27 in infected patients was positively correlated with TBil. The expression of IL-27 in CHB group was positively correlated with ALT. The expression of IL-27 in LC group was positively correlated with AST and TBil. Conclusion IL-27 is highly expressed in the peripheral blood of patients with chronic HBV infection and is associated with liver inflammation during the course of chronic HBV infection.