论文部分内容阅读
淋病奈瑟氏球菌引起的淋病是我国目前流行的性传播疾病中发病率最高的病种[1 ] 。传统的抗生素如青霉素、四环素由于耐药菌株的普遍存在已不再应用于临床治疗 ,然而 ,淋病奈瑟氏球菌对这类药物的耐药仍广泛存在。喹诺酮是近几年来治疗淋病最有效的抗生素 ,但目前已出现了对这些抗生素的耐药菌株 ,且随着抗生素的广泛应用有日渐增加的趋势[2 ] 。了解淋病奈瑟氏球菌耐药的发生机制、掌握并使用快速敏感的耐药基因检测方法是及时发现耐药菌株的关键 ,也是临床合理使用抗生素的前提。本文综述了淋病奈瑟氏球菌耐药现状、对几种常用药物的耐药机制及耐药基因的检测的研究
Gonorrhea caused by Neisseria gonorrhoeae is currently the most prevalent disease in sexually transmitted diseases in China [1]. Traditional antibiotics such as penicillin and tetracycline are no longer used for clinical treatment due to the prevalence of drug-resistant strains. However, the drug resistance of Neisseria gonorrhoeae to these drugs is still widespread. Quinolones are the most effective antibiotics for the treatment of gonorrhea in recent years. However, resistant strains of these antibiotics have emerged at present, and their antibiotics have a tendency of increasing with the wide application of antibiotics [2]. To understand the mechanism of Neisseria gonorrhoeae drug resistance, to master and use rapid and sensitive drug-resistant gene detection method is the key to timely detection of drug-resistant strains, but also the premise of clinical rational use of antibiotics. This review summarizes the drug resistance of Neisseria gonorrhoeae, the mechanism of resistance to several commonly used drugs and the detection of drug resistance genes