论文部分内容阅读
目的评价生长激素(GH)运动筛查试验和GH激发试验对儿童生长激素缺乏症的诊断价值。方法选取200例身材矮小患儿,均符合身材矮小诊断标准,无骨代谢、糖尿病等其他内分泌代谢疾病。对患儿均进行GH运动筛查试验及GH激发试验。GH激发试验包括精氨酸激发试验、左旋多巴激发试验及胰岛素激发试验,本研究中所有患儿在3种GH激发试验中任选2种。2种试验均采用放射免疫法进行检测。结果身材矮小患儿行GH运动试验和GH激发试验的GH峰值强度分别为(12.78±6.98)μg/L和(14.07±5.89)μg/L,二者GH峰值比较无显著性差异(t=1.87 P>0.05)。200例患儿中GH激发试验和运动试验均阳性者29例;运动试验阳性而GH激发试验阴性者5例,运动试验存在2.5%假阳性率。2种试验方法阳性率间比较无统计学差异(χ2=0.47 P>0.05)。结论GH运动筛查试验和GH激发试验得出的结果具有很高的一致性。由于运动试验具有操作简单、安全等优点,应将GH运动筛查试验作为身材矮小患儿的首选筛查试验。
Objective To evaluate the diagnostic value of growth hormone (GH) screening test and GH provocation test in children with growth hormone deficiency. Methods 200 cases of short stature children were selected, all in line with short stature diagnostic criteria, no bone metabolism, diabetes and other endocrine and metabolic diseases. GH children were screened for GH test and GH challenge test. GH provocation tests include arginine provocation test, levodopa challenge test, and insulin provocation test. All of the patients in this study selected two of the three GH provocation tests. Two kinds of tests were detected by radioimmunoassay. Results The GH peak intensities of GH exercise test and GH challenge test were (12.78 ± 6.98) μg / L and (14.07 ± 5.89) μg / L, respectively. There was no significant difference in GH peak between the two groups (t = 1.87 P> 0.05). There were 29 cases of GH provocation test and exercise test positive in 200 cases; 5 cases were positive in exercise test but negative in GH provocation test, and 2.5% in sports test. There was no significant difference between the two test methods (χ2 = 0.47 P> 0.05). Conclusions The results obtained by the GH screening test and the GH provocation test are highly consistent. As the exercise test is simple, safe, GH screening test should be used as the preferred screening test for children with short stature.