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(Pagge R.)Tarpan, ein hochwirksames, Chemisch neuartiges Antihistamin. 《Schw-eiz. Med. Wschr.》 1963. 5 №3, 148-150. (德文) Tarpan在化学上为一种新型的,由Dibenzodiazepine衍生的化合物。用一般的药理学研究方法征明,是一种口服、有强效的抗组织胺药。对豚鼠由组织胺引起的哮喘,尤其对豚鼠过敏性休克,作用最为突出,口服LD_(50)的1/2000,可减少动物的一半死亡数;如用100倍于抗过敏的剂量时,方使小鼠呈现镇静作用。慢性毒性试验,每天按75
(Pagge R.) Tarpan, ein hochwirksames, Chemisch neuartiges Antihistamin. “Schw-eiz. Med. Wschr.” 1963. 5 № 3, 148-150. (German) Tarpan is chemically a novel compound derived from Dibenzodiazepine Derived compounds. With the general pharmacological research methods that is an oral, potent antihistamine. Asthma caused by histamine in guinea pigs, especially the guinea pig anaphylactic shock, the most prominent role, oral LD_ (50) 1/2000, can reduce the number of animal deaths by half; such as with 100 times the dose of anti-allergy, the side Makes the mice sedative. Chronic toxicity test, press 75 per day