本文讨论实验性肝损害与内毒素血症的关系,以及网状内皮细胞系统功能状态对此二者的影响,资料显示内毒素在 D-氨基半乳糖、四氯化碳及蛙病毒等所致急性肝坏死模型的发病机制中均居重要地位。更深入的研究则证明,上述实验性肝损害常先有网状内皮细胞系统形态与功能的损害,导致严重地破坏肝脏对内毒素的解毒作用,进而引起肝实质广泛损害。 This article discusses the relationship between experimental liver damage and endotoxemia, as well as the functional status of the reticuloendothelial system affect the two, the data show endotoxin in D-galactosamine, carbon tetrachloride and frog virus caused by The pathogenesis of acute liver necrosis model occupies an important position. More in-depth studies have shown that these experimental liver damage often have the reticuloendothelial system morphology and function of the damage, leading to a serious damage to liver detoxification of endotoxin, which in turn cause widespread damage to the liver parenchyma.