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目的探讨和分析氨茶碱联合盐酸氨溴索治疗小儿支气管哮喘的临床疗效。方法选取2011年1月至2012年6月期间在我院接受治疗的46例支气管哮喘患儿,随机分成治疗组和对照组,每组23例。两组分别采用不同的治疗方法,对照组给予氨茶碱4mg(/kg·d)分两次静脉滴注、抗感染、糖皮质激素、止咳化痰、维持水电解质和酸碱平衡等常规治疗;治疗组在对照组治疗方法的基础上,联合盐酸氨溴索1.5mg(/kg·d)分两次静脉滴注进行治疗。治疗四个疗程后,观察两组患儿的临床症状的改善情况。结果对照组总有效率为78.26%,治疗组的总有效率为91.30%,两组比较差异具有统计学意义,且治疗组喘憋、喘鸣音、及咳嗽消失时间明显短于对照组。结论氨茶碱联合盐酸氨溴索治疗小儿支气管哮喘的临床效果显著,无明显的不良反应症状,能够明显的改善患儿的病情,具有临床推广和应用的价值。
Objective To investigate and analyze the clinical efficacy of aminophylline combined with ambroxol hydrochloride in the treatment of pediatric bronchial asthma. Methods 46 children with bronchial asthma who were treated in our hospital from January 2011 to June 2012 were randomly divided into treatment group and control group, with 23 cases in each group. The two groups were treated with different methods, the control group was given aminophylline 4mg (/ kg · d) by two intravenous drip, anti-infective, glucocorticoid, cough and phlegm to maintain water and electrolyte and acid-base balance and other conventional treatment ; Treatment group in the control group on the basis of treatment, combined with ambroxol 1.5mg (/ kg · d) were treated by two intravenous drip. After four courses of treatment, the improvement of clinical symptoms in both groups was observed. Results The total effective rate of the control group was 78.26%, and the total effective rate of the treatment group was 91.30%. The difference between the two groups was statistically significant. The time of wheezing, wheezing and cough disappearing in the treatment group was significantly shorter than that in the control group. Conclusion The combination of aminophylline and ambroxol hydrochloride in the treatment of bronchial asthma in children has obvious clinical effect, no obvious adverse reaction symptoms, which can obviously improve the condition of children and has the value of clinical popularization and application.