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目的分析轻中度高血压采用硝苯地平缓释剂治疗的临床疗效和药理作用。方法 108例轻中度高血压患者,随机分为观察组与对照组,每组54例。观察组给予硝苯地平缓释剂治疗,对照组给予苯磺酸氨氯地平片治疗,对比两组血压水平及药物安全性。结果两组治疗前收缩压、舒张压对比,差异无统计学意义(P>0.05);治疗后两组患者血压对比,差异具有统计学意义(P<0.05);观察组不良反应发生率为5.56%,对照组不良反应发生率为22.22%,对比差异具有统计学意义(P<0.05)。结论硝苯地平缓释剂治疗轻中度高血压的临床疗效显著,不良反应少,临床推广价值高。
Objective To analyze the clinical efficacy and pharmacological effects of nifedipine sustained-release agent in mild to moderate hypertension. Methods A total of 108 patients with mild to moderate hypertension were randomly divided into observation group and control group, with 54 cases in each group. The observation group was given nifedipine sustained-release agent, the control group was treated with amlodipine besylate tablets, and the blood pressure and drug safety were compared between the two groups. Results There was no significant difference in systolic blood pressure and diastolic blood pressure between the two groups before treatment (P> 0.05). There was significant difference in blood pressure between the two groups after treatment (P <0.05). The incidence of adverse reactions in the observation group was 5.56 %, The incidence of adverse reactions in the control group was 22.22%, the difference was statistically significant (P <0.05). Conclusion Nifedipine sustained-release agent is effective in treating mild to moderate hypertension with less adverse reactions and high clinical value.