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目的 探讨Behcet病和Vogt Koyanagi Harada(VKH)综合征的脉络膜视网膜病变特征。方法 对 17例 (2 7只眼 )具有活动性葡萄膜炎的Behcet病和 18例 (36只眼 )VKH综合征患者行吲哚青绿血管造影术 (indocyaninegreenangiography ,ICGA)和荧光素眼底血管造影术 (fundusfluoresceinangiography,FFA)检查 ,对其脉络膜视网膜进行观察。结果 Behcet病患者中 ,FFA检查显示均有视网膜微血管渗漏 ;ICGA检查发现 11只眼 (40 7% )有脉络膜血管扩张 ,通透性增强。VKH综合征患者中 ,FFA后期检查可见视网膜微血管呈多湖状染料积存、视盘染色或弥散性视网膜色素上皮 (retinalpigmentepithelium ,RPE)损害 ;ICGA检查 ,发现 36只眼 (10 0 0 % )脉络膜血管扩张、通透性增强 ,其中多灶性弱荧光斑 32只眼 (88 9% ) ,脉络膜灌注不良 2 8只眼 (77 8% )。结论 Behcet病是以视网膜血管炎为主的炎性病变 ,但脉络膜亦可受累 ;VKH综合征主要累及脉络膜和RPE ,ICGA主要表现为脉络膜血管扩张和多灶性弱荧光。FFA与ICGA结合能全面了解Behcet病和VKH综合征的脉络膜视网膜病变特征和损害形式
Objective To investigate the characteristics of chorioretinopathy in Behcet’s disease and Vogt Koyanagi Harada’s (VKH) syndrome. Methods Seventeen patients (27 eyes) with active uveitis and 18 patients (36 eyes) with VKH syndrome underwent indocyanine green angiography (ICGA) and fluorescein fundus angiography (fundus fluorescein angiography, FFA) examination of the choroidal retina was observed. Results In Behcet’s disease, FFA showed retinal microvascular leakage. In ICGA examination, choroidal vasodilation and permeability were found in 11 eyes (40.7%). In VKH syndrome, retinal microvessels were found to accumulate lakes-like dye, optic disc staining or disseminated retinal pigment epithelium (RPE) damage in post-FFA examination. ICGA examination revealed choroidal vasodilation in 36 eyes (100%) , Permeability increased, including multifocal weak fluorescence spots in 32 eyes (88 9%), choroidal perfusion 28 eyes (77 8%). Conclusions Behcet’s disease is a retinal vasculitis-based inflammatory disease, but the choroid may also be involved. VKH syndrome mainly involves the choroid and RPE. ICGA mainly manifests as choroidal vasodilation and multifocal weak fluorescence. The combination of FFA and ICGA provides a comprehensive understanding of the choroidal retinopathy features and forms of damage in Behcet’s and VKH syndromes