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我院自1986年1月～4月应用血液流变学改善剂己酮可可碱(pentoxifylline,商名Trental,西德产)对36例脑动脉硬化及冠口病患者进行临床应用观水,初步报道如下·资料与方法男22例,女14例。年龄37一80岁。其中冠心病心肌梗塞10例,冠心病心纹痛12例,高血压脑动脉硬化14例。全部病例入院时均伴有高粘血症。用药方法为全部病例均不加用其他作用于心血管及抗凝活性的药物,单一应用己酮可可碱治疗。剂尽为何日口服3次,傅次2。。毫克。全部病例在用药前均进行详细检查并记录:临床症状、血压、心率、自细胞计数、红细胞压积、血小板计数、血小板凝集率、血浆比估度、全血比粘度、心砚杭血流日测定心脏指数、心搏指数及总外周血管阻力。治疗开始后每日记录临床症状、血压、心率,其他各项检卉则于治疗第10天全部复查,进行治疗前后对比分析。结果在应用已酮可可碱后,临床症状绝大多数均可有效缓解。治疗前有头晕头痛者邪例,治疗后功。%缓解;治疗前胸闷心绞痛者拐例,治疗后12例‘92.3%)缓解;四肢发麻者2例,心慌心悸者2例亦均于治疗后缓解。36例患者的血压、心率、自细胞计数,红细胞压积及血小板计数,血浆比粘度等6项指标,治疗前后结果经统计学对比处理后,P值大于。.05,均无显著意义。
In our hospital from January 1986 to April application of hemorheology to improve the pentoxifylline (pentoxifylline, trade name Trental, West Germany) on 36 cases of cerebral arteriosclerosis and coronavirus patients clinical observation of water, preliminary Reported as follows · Materials and Methods Male 22 cases, 14 females. Age 37-80 years old. Including coronary heart disease in 10 cases, coronary heart disease in 12 cases of heartache, hypertensive cerebral arteriosclerosis in 14 cases. All cases were accompanied by hyperviscosity when admitted to hospital. Medication method for all cases were not added with other drugs on cardiovascular and anticoagulant activity, a single application of pentoxifylline treatment. Why daily oral 3 times, Fu times 2. . Mg. All cases were carefully examined before treatment and recorded: clinical symptoms, blood pressure, heart rate, self-cell count, hematocrit, platelet count, platelet aggregation rate, plasma ratio estimate, whole blood specific viscosity, Heart index, heart rate index and total peripheral vascular resistance were measured. After the start of treatment, clinical symptoms, blood pressure and heart rate were recorded daily. All other tests were reviewed on the 10th day of treatment and compared before and after treatment. Results In the application of pentoxifylline, the vast majority of clinical symptoms can be effectively alleviated. Dizziness and headache before treatment are evil cases, after treatment. % Relieved; treatment of chest anorexia before angina cases, 12 cases after treatment ’92 .3%) ease; limb numbness in 2 cases, palpitation in 2 cases were also relieved after treatment. 36 patients were blood pressure, heart rate, self-cell count, hematocrit and platelet count, plasma viscosity and other six indicators, before and after treatment by statistical comparison, P value greater than. .05, no significant significance.