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目的:探讨系统性红斑狼疮(SLE)患者血清免疫球蛋白水平与肾损伤发生的相关性。方法:前瞻性纳入2018年1月至2019年6月河南省人民医院收治82例SLE患者，测定所有患者免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平，设计基线资料调查表详细记录患者一般资料，分析免疫球蛋白水平与SLE患者肾损伤发生的关系。结果:82例SLE患者中发生肾损伤23例，发生率为28.05%(23/82)。发生肾损伤SLE患者的IgA、IgG、IgM水平均高于未发生肾损伤的SLE患者，差异有统计学意义(n P1，n P<0.05)。n 结论:SLE患者肾损伤发生与IgA、IgG、IgM水平表达有关，上述指标过表达可能参与了肾损伤的发生进程。“,”Objective:To analyze the correlation between the serum immunoglobulin levels and renal injury in patients with systemic lupus erythematosus (SLE).Methods:Eighty-two SLE patients treated in Henan Provincial People’s Hospital from January 2018 to June 2019 were prospectively enrolled in the study. The levels of immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) of all patients were measured. A baseline questionnaire was designed to record the general data of patients in detail. And the relationship between immunoglobulin level and renal injury in SLE patients was analyzed.Results:Among 82 SLE patients, 23 cases had renal injury, and the incidence was 28.05%(23/82). The levels of IgA, IgG and IgM in SLE patients with renal injury were significantly higher than those in SLE patients without renal injury (n P1,n P<0.05).n Conclusions:The expression of IgA, IgG and IgM is related to the occurrence of renal injury in SLE patients. Over expression of IgA, IgG and IgM may be involved in the development of renal injury.