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目的:观察不同病期原发性肾病综合征(NS)的血脂变化及其变化规律。方法:对40例NS 患儿在活动期和缓解期(激素改隔日疗法时)血清总胆固酯(TC)、甘油三酯(TG),高密度脂蛋白胆周醇醋(HDL-Ch)、载脂蛋白 AI(APO-AJ)和载脂蛋白 B_(100)(APO-B_(100))进行检测。结果:活动期NS 患儿 TC(9.88±2.59)mmol/L、TG(3.06±1.72)mmol/L、APO-B_(100)(2.37±0.46)g/L,水平明显高于对照组(P<0.01),APO-AI、HDL-Ch 水平也高于对照组,但差异无显著性,缓解期 NS 患儿 TC(7.61±1.82)mmol/L、TG(2.45±1.84)mmol/L、APO-B_(100)(2.12±0.42)g/L 水平较活动期水平降低,但仍高于对照组(P<0.05)。结论:NS 患儿无论在活动期或缓解期均有明显的脂代谢异常,有必要早期应用降脂药物,以减轻肾损害和心血管并发症。
Objective: To observe the changes of lipid profile and its changes in primary nephrotic syndrome (NS) at different stages. Methods: The serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol and cholesterol (HDL-Ch) in 40 NS children during active phase and remission period , Apolipoprotein AI (APO-AJ) and apolipoprotein B (100) (APO-B_ (100)) were detected. Results: The levels of TC (9.88 ± 2.59) mmol / L, TG (3.06 ± 1.72) mmol / L and APO-B_ (100) (2.37 ± 0.46) g / L in active NS patients were significantly higher than those in control group (P <0.01). The levels of APO-AI and HDL-Ch in the remission children were also higher than those in the control group The level of B_ (100) (2.12 ± 0.42) g / L was lower than that of the control group (P <0.05). Conclusion: There are obvious lipid metabolism abnormalities in children with NS both in active stage and remission stage. It is necessary to apply lipid-lowering drugs in early stage to reduce renal damage and cardiovascular complications.