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目的:分析石油作业女性外周血淋巴细胞姐妹染色单体互换(SCE)对习惯性流产的影响。方法:随机选择习惯性流产的石油作业女性26人为观察组和正常的育龄女性18人为对照组,检测其外周血淋巴细胞姐妹染色单体互换,记数SCE发生率。结果:观察组的外周血淋巴细胞SCE发生率为8.66±0.61明显高于对照组,差异有统计学意义(P<0.05)。结论:SCE的发生可作为石油作业习惯性流产女性染色体结构稳定性的检测指标。石油作业环境中的某些有害物质对女性DNA损伤有一定的影响。
OBJECTIVE: To analyze the effect of sister chromatid exchange (SCE) on peripheral blood lymphocytes of pregnant women on habitual abortion. Methods: Twenty-six females in observation group and 18 normal women of childbearing age were randomly selected as the control group. The detection rate of sister chromatid exchange and count SCE in peripheral blood lymphocytes were detected. Results: The incidence of SCE in peripheral blood lymphocytes in observation group was 8.66 ± 0.61, which was significantly higher than that in control group (P <0.05). Conclusion: The occurrence of SCE can be used as a measure of the structural stability of female chromosomes in habitual abortion in petroleum operations. Some harmful substances in the petroleum operating environment have a certain impact on DNA damage in women.