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目的探讨新疆地区人乳头状瘤病毒(human papillomavirus,HPV)感染与乳腺癌临床组织病理间的关系。方法 325例乳腺癌患者癌组织(乳腺癌组)和65例乳腺腺病患者乳腺组织(对照组),2组提取DNA,采用基因芯片技术检测乳腺癌中HPV DNA并进行分型,分析HPV感染与乳腺癌组织病理间的关系。结果乳腺癌组HPV阳性率11.7%,对照组9.2%,差异无统计学意义(P>0.05);乳腺癌组主要为HPV16感染,对照组主要为HPV11感染;乳腺癌组HPV感染在导管癌分化程度上差异有统计学意义(P<0.05),在肿瘤大小、肿瘤类型、淋巴结转移情况、雌激素受体、孕激素受体、人类表皮生长因子受体2表达情况及临床分期上差异无统计学意义(P>0.05)。结论 HPV感染与新疆地区乳腺癌的发生、发展不存在相关性。
Objective To investigate the relationship between human papillomavirus (HPV) infection and clinical histopathology in breast cancer in Xinjiang. Methods 325 cases of breast cancer patients with breast cancer (breast cancer group) and 65 cases of breast adenosis patients with breast tissue (control group), two groups of DNA extraction, detection of HPV DNA in breast cancer using gene chip technology and typing, analysis of HPV infection And breast cancer histopathological relationship. Results The positive rate of HPV was 11.7% in breast cancer group and 9.2% in control group, with no significant difference (P> 0.05). The HPV16 infection in breast cancer group and HPV11 infection in control group were the most common. (P <0.05). There was no statistical difference in tumor size, tumor type, lymph node metastasis, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 expression and clinical stage Significance (P> 0.05). Conclusion There is no correlation between HPV infection and the occurrence and development of breast cancer in Xinjiang.