论文部分内容阅读
目的探讨T2DM患者下肢血管病变与微量尿白蛋白(MAU)、尿白蛋白/尿肌酐(UACR)及其影响因素的相关性。方法选取T2DM患者210例,根据下肢血管超声分为正常或狭窄<30%组、狭窄30%~49%组、狭窄50%~75%组及狭窄>75%或闭塞组。测定各组HbA_1c、UACR、LDL-C、HDL-C、Scr等。结果狭窄>75%或闭塞组糖尿病病程、UACR、HbA_1c、LDL-C高于正常或狭窄<30%和狭窄30%~49%组(P<0.05)。相关分析显示,血管狭窄程度与糖尿病病程、UACR、HbA_1c、TC、LDL-C、Scr呈正相关(r=0.310、0.760、0.407、0.324、0.260、0.589,P<0.05),与HDL-C呈负相关(r=0.460,P<0.05)。Logistic回归分析显示,UACR、LDL-C是糖尿病下肢动脉狭窄的独立相关因素。结论 UACR是糖尿病下肢血管病变的独立相关因素,随着蛋白尿程度的增加,下肢动脉狭窄程度加重。
Objective To investigate the relationship between lower extremity vascular lesions and microalbuminuria (MAU), urinary albumin / urinary creatinine (UACR) and its influencing factors in patients with T2DM. Methods Totally 210 patients with T2DM were divided into three groups: normal or stenosis <30%, stenosis 30% ~ 49%, stenosis 50% ~ 75%, stenosis> 75% or occlusion group according to the lower extremity vascular ultrasound. HbA_1c, UACR, LDL-C, HDL-C and Scr were determined in each group. Results The duration of diabetes (≥ 75%) or duration of occlusion (UACR, HbA_1c, LDL-C) were significantly higher than those of normal or stenosis <30% and stenosis of 30% ~ 49% (P <0.05). Correlation analysis showed that the degree of vascular stenosis was positively correlated with duration of diabetes, UACR, HbA 1c, TC, LDL-C and Scr (r = 0.310,0.760,0.407,0.324,0.260,0.589, P <0.05) (R = 0.460, P <0.05). Logistic regression analysis showed that UACR and LDL-C were independent independent factors of arterial stenosis in lower extremities of diabetic patients. Conclusions UACR is an independent factor related to lower extremity vascular disease in diabetic patients. With the increase of proteinuria, lower extremity arterial stenosis is aggravated.