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目的:探讨运用血栓弹力图检测老年患者服用抗血小板药物后血小板抑制率的变化。方法:通过本院就诊60例老年患者,运用血栓弹力图测得AA和ADP途径诱导的血小板抑制率,将患者分成阿司匹林组(Ⅰ组)、氯吡格雷组(Ⅱ)、阿司匹林+氯吡格雷组(Ⅲ组),与正常对照组(Ⅳ组)30例进行统计分析。结果:60例患者中,阿司匹林组AA诱导的血小板抑制率为87.1±20.8%,氯吡格雷组ADP诱导的血小板抑制率为48.6±24.3%,阿司匹林+氯吡格雷组AA诱导和ADP诱导的血小板抑制率为分别92.2±13.1%和53.9±23.2%,血小板抑制率均显著高于对照组(P<0.01)。结论:通过血栓弹力图能客观地反映老年患者服用抗血小板药物后血小板抑制率的变化,阿司匹林抗血小板作用优于氯吡格雷,同时服用阿司匹林和氯吡格雷能起到更强的抗血小板作用。
Objective: To investigate the change of platelet inhibitory rate after taking antiplatelet drugs in elderly patients by using thromboelastography. Methods: Sixty elder patients were treated in our hospital. Thromboelastometry was used to measure the platelet inhibition rate induced by AA and ADP. The patients were divided into aspirin group (group Ⅰ), clopidogrel group (Ⅱ), aspirin + clopidogrel (Group Ⅲ), and normal control group (group Ⅳ) 30 cases were statistically analyzed. Results: In the 60 patients, AA-induced platelet inhibition rate was 87.1 ± 20.8% in aspirin group and 48.6 ± 24.3% in clopidogrel-treated ADP group. AA induced by aspirin + clopidogrel group and ADP-induced platelet The inhibitory rates were 92.2 ± 13.1% and 53.9 ± 23.2%, respectively. The inhibition rates of platelets were significantly higher than those of the control group (P <0.01). Conclusion: Thromboelastography can objectively reflect the change of platelet inhibitory rate after taking antiplatelet drugs in elderly patients. Aspirin is more effective than clopidogrel in antiplatelet activity, and aspirin and clopidogrel can play a more effective antiplatelet effect.