胃炎促愈汤对胃溃疡患者溃疡病灶愈合进程的影响及作用机制分新

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目的:探讨中医胃炎促愈汤治疗胃溃疡患者的效果及其作用机制.方法:选取2015年1月~2015年12月在我院消化内科治疗的120例胃溃疡患者,采用SAS10.0软件生成随机数字分为中医辅助组、常规组各60例,两组患者均给予奥美拉唑、阿莫西林、替硝唑治疗,中医辅助组同时采用胃炎促愈汤治疗,服用时间4周.结果:治疗后,中医辅助组患者胃脘疼痛、空腹痛、厌食、嗳气反酸、黑便评分均低于常规组(P<0.05),中医辅助组胃泌素低于常规组(P<0.05),NO、NOS、VEGF水平高于常规组(P<0.05);治疗后内镜下观察,中医辅助组痊愈率46.67%、显效率36.67%,常规组为33.33%、30.00%,两组比较差异具有统计学意义(P<0.05);治疗后临床效果评价,中医辅助组患者的痊愈率40.00%、显效率41.67%,常规组为30.00%、31.67%,两组比较差异具有统计学意义(P<0.05).结论:中医胃炎促愈汤治疗胃溃疡患者能够提高NO、NOS、VEGF水平,降低胃泌素水平,促进溃疡愈合.“,”Objective:To investigate the effect and mechanism of treating gastric ulcer with Weiyan Cuyu Decoction.Methods:A total of 120cases of gastric ulcer patients from January 2015to December 2015in the department of fastroenterology in our hospital,using SAS10.0software to generate randomly divided into TCM auxiliary group,normal group,60cases in each group,two groups of patients were given omeprazole,amoxicillin and tinidazole in the treatment group,TCM auxiliary group was given Weiyan Cuyu Decoction at the same time,taking time for 4weeks.Results:After treatment,TCM group patients with epigastric pain,pain,anorexia,belching and acid regurgitation,fasting and melena scores were lower than the normal group (P<0.05),TCM group were lower than that of the normal group of gastrin (P<0.05),NO,NOS,VEGF levels were higher than the normal group (P<0.05);After treatment under endoscope,the cure rate of the traditional Chinese medicine group was 46.67%,the efficiency was 36.67%,the controlled group was 33.33% and 30%,with significant differences between the two groups (P< 0.05);To evaluate the clinical effect after treatment,the cure rate of the TCM group was 40%,the effective rate was 41.67%,the normal group was 30%,31.67%,two groups had significant difference (P<0.05).Conclusion:The treatment of gastric ulcer can improve the level of NO,NOS and VEGF,reduce the level of gastrin,and promote the healing of ulcer.
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