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临床上很多心动过缓的病人需要安装起搏器,但经过长期的发展起搏器仍有很多缺陷。为了弥补起搏器的不足,生物起搏器应运而生,且通过模拟起搏细胞功能到模拟起搏细胞表型和功能再到使正常心肌细胞重编程为起搏细胞及调节起搏细胞下游通路等研究,生物起搏器已经可以在大动物心脏中稳定且持久的起效。但投入到临床应用之前,生物起搏器还有很长的路要走。
Many clinical bradycardia patients need to install pacemakers, but after long-term development pacemaker still has many shortcomings. In order to compensate for the shortage of pacemakers, biological pacemakers came into being, and by simulating the function of pacemaker cells to simulate the phenotype and function of pacemaker cells and then to reprogram normal cardiomyocytes to pacemaker cells and to regulate downstream of pacemaker cells Pathways and other research, biological pacemaker can already be stable and long-lasting effect in the heart of large animals. However, biological pacemakers have a long way to go before they are put into clinical application.