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目的探索先天性眼球震颤（ＣＮ）的发病机理，了解其脑血流动力学的改变。方法应用单光子发射型计算机断层显像技术（ＳＰＥＣＴ），对２７例ＣＮ患者进行脑血流灌注显像及半定量分析。结果（１）跳动型ＣＮ：快相侧额叶皮质脑血流灌注量均减弱，慢相侧额叶脑血流灌注增强（占６６．６７％），其枕叶灌注量降低。（２）钟摆型ＣＮ：两侧额叶皮质脑血流灌注量均减少，皮质层变薄。结论提示ＣＮ患者大脑额叶、枕叶部分区域脑血流灌注异常，这可能造成该区神经功能不平衡，导致眼球运动中枢功能失调。
Objective To explore the pathogenesis of congenital nystagmus (CN) and to understand its hemodynamic changes. Methods Single photon emission computed tomography (SPECT) was used in 27 CN patients for cerebral perfusion imaging and semi-quantitative analysis. Results (1) Beating CN: The fasting side frontal cortex cerebral blood flow perfusion decreased, slow side frontal lobe cerebral perfusion increased (66.67%), the occipital lobe perfusion decreased. (2) pendulum type CN: frontal cortex on both sides of cerebral blood flow were reduced, cortical thinning. Conclusions These findings suggest that abnormal brain perfusion in the frontal lobe and occipital lobe of CN patients may lead to imbalance of neurological function and dysfunction of central ocular motility.