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为了解口服Ⅱ号避孕药对血小板功能及血液凝固性的影响,本文对65名连续服药妇女进行了研究。她们的年龄为27～45(平均36.5)岁。服药期限1～17(平均6.7)年。测定项目有纤维蛋白原,血小板粘附率,血小板聚集率,Ⅷ因子相关抗原,抗凝血酶活力等。20例未服药妇女作对照。测定结果服药组血小板粘附率、聚集率及纤维蛋白原比对照组明显增高(P<0.001)。Ⅷ因子相关抗原略增高,但无统计学意义。抗凝血酶活力显著降低(P<0.001)。本文就急性心肌梗塞及血栓栓塞的潜在可能性等问题进行了讨论,并对预防此类并发症提出了建议。
To understand the effect of oral contraceptives on platelet function and blood clotting, 65 consecutive women taking medication were studied. Their age ranged from 27 to 45 (mean, 36.5) years. Medication period 1 to 17 (average 6.7) years. Determination of fibrinogen, platelet adhesion rate, platelet aggregation rate, Ⅷ factor-related antigen, antithrombin activity. Twenty women who did not take medicine as control. The results showed that the platelet adhesion rate, aggregation rate and fibrinogen in the medication group were significantly higher than those in the control group (P <0.001). Factor Ⅷ related antigen slightly increased, but not statistically significant. Antithrombin activity was significantly reduced (P <0.001). This article discusses the issues of acute myocardial infarction and the potential for thromboembolism, and provides recommendations for the prevention of such complications.